Obesity Abstracts

We present the case of a 28-year-old woman who initially presented aged 11 with a brain tumour in 2002. This was diagnosed as a craniopharyngioma and managed with neurosurgery, a ventriculoperitoneal (VP) shunt and radiotherapy. The consequence of this treatment gradually rendered her panhypopituitary and caused hypothalamic injury. Medications which were commenced around this time include hydrocortisone, thyroxine, desmopressin and growth hormone. The hypothalamic insult in t...

Obesity is a global crisis associated with other metabolic diseases such as cardiovascular disease and Type 2 Diabetes (T2D). Current pharmacological therapies, including metformin, are prescribed for T2D to control blood glucose levels, however, treatment may be accompanied by undesirable side effects. Compound 14 (Cpd14) is a recently developed compound shown to promote weight loss and improve glucose metabolism in high-fat diet (HFD)-fed mice, treated intraperitoneally for ...

The ABUHB level 3 adult weight management service provides individualized 2-year multidisciplinary support for patients with severe obesity and associated multi-morbidity. Some patients are discharged before 2 years or voluntarily leave the service early. To date, this service has received >400 referrals from 5 local authority areas as well as out-of-area referrals. The prevalence of adult obesity (BMI≥30.0 kg/m2 and ≥40.0 kg/m2) in the ABUHB ...

Introduction: Obesity is a non-communicable disease with increasing prevalence and complications in our society. Previous systematic review of published papers on obesity in Nigeria showed its prevalence ranged from 8.1% to 22.2% while overweight ranged from 20.3% to 35.1%.Objective: To evaluate the prevalence and associations of obesity and hypertension among civil servants in a state in North Central Nigeria.Methods: This was a p...

The study determines the prevalence and lifestyle predictors of metabolic health (MH) among normal weight and obese individuals within a Maltese cohort using two main approaches a) the Metabolic Syndrome (Met-S) framework as per NCEP-ATPIII and b) Insulin Resistance (IR) as defined by HOMA-IR; and to determine which cut-off valueof HOMA-IR best predicts metabolic health. This was a cross sectional study. Subjects with a BMI <25 kg/m2 were considered normal weigh...

Background: According to the World Health Organization (WHO), the United Arab Emirates (UAE) has one of the highest prevalence rates of obesity in the Middle East at 33%. There is a paralleled rise in the incidence of related metabolic conditions, particularly type 2 diabetes, metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Through dietary, pharmaceutical, endoscopic and surgical options, multidisciplinary weight reduction programs offer a comprehensive appro...

Excess body weight is associated with increased risk of colorectal cancer. Obesity surgery (OS) is increasingly performed in individuals who are ‘morbidly’ obese. Increased CRC risk was particularly evident greater than ten years after OS and was similar for gastric bypass, gastric banding and gastroplasty. By contrast, CRC risk in non-operated obese individuals remained stable according to the literature review. We present a 35 year old male, who underwent laparosco...

Background: Hyperglucagonaemia is one of the key players in the pathophysiology of type 2 diabetes. Roux-en-Y Gastric Bypass (RYGB) is currently a highly effective treatment for weight loss and diabetes remission. However, the role of glucagon in the above effects is unclear.Aim: To characterise the behaviour of proglucagon-derived peptides (glucagon, glucagon-like peptide-1, oxyntomodulin, glicentin) after RYGB surgery.Subjects an...